Document Detail

Systematic review: the use of nitrous oxide gas for lower gastrointestinal endoscopy.
MedLine Citation:
PMID:  20491748     Owner:  NLM     Status:  In-Process    
BACKGROUND: Nitrous oxide gas (N(2)O) has been proposed as an alternative to intravenous (i.v.) analgesia in patients undergoing lower gastrointestinal endoscopy.
AIM: To perform a systematic review of randomized studies where N(2)O was compared against control in patients undergoing either flexible sigmoidoscopy or colonoscopy.
METHODS: Electronic databases were searched; reference lists were checked and letters were sent to authors requesting data. Methodological quality was assessed. Data were tabulated on the duration and difficulty of the procedure, quality of sedation and speed of patient recovery.
RESULTS: A total of 11 studies were identified containing 623 patients. No differences were seen between groups for duration, difficulty of procedure or complications. Patient-reported pain was similar for N(2)O when undergoing flexible sigmoidoscopy vs. no sedation and when undergoing colonoscopy vs. i.v. sedation. Differences in delivery of N(2)O were identified. In all studies, N(2)O was associated with a more rapid recovery than i.v. sedation.
CONCLUSION: For patients undergoing colonoscopy, N(2)O provides comparable analgesia to i.v. sedation. The rapid psychomotor recovery with N(2)O enables quicker patient discharge and removes the need for a patient to be chaperoned. Benefit was not seen from N(2)O in patients undergoing flexible sigmoidoscopy possibly because it was delivered on demand rather than continuously.
S Welchman; S Cochrane; G Minto; S Lewis
Related Documents :
19619188 - Midazolam as a sole sedative for computed tomography imaging in pediatric patients.
14720528 - Overweight and obesity in patients with established coronary heart disease: are we meet...
15562908 - Effects of intravenous midazolam and diazepam on patient response, percentage of oxygen...
18630768 - Effect of bispectral index (bis) monitoring on postoperative recovery and sevoflurane c...
7932918 - Characterization of 4-aminopyridine in overdose.
6607068 - Supernormal scotopic erg in cone dystrophy.
Publication Detail:
Type:  Journal Article     Date:  2010-05-18
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  32     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-33     Citation Subset:  IM    
Department of Surgery, Derriford Hospital, Plymouth, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Comment In:
Endoscopy. 2011 Jan;43(1):63-6   [PMID:  21234844 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical trial: impact of prior infliximab therapy on the clinical response to certolizumab pegol ma...
Next Document:  Systematic review: role of acid, weakly acidic and weakly alkaline reflux in gastro-oesophageal refl...