| Systematic review of the treatment of cancer-associated anorexia and weight loss. | |
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MedLine Citation:
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PMID: 16293879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We systematically assessed the efficacy and safety of appetite stimulants in the management of cancer-related anorexia. Literature databases were searched for randomized controlled trials of appetite stimulants in the treatment of cancer anorexia. MATERIALS AND METHODS: Studies were graded according to quality. Fifty-five studies met inclusion criteria. RESULTS: Only two drugs have evidence to support their use for anorexia (progestins and corticosteroids). There is strong evidence against the use of hydrazine sulfate. The outcomes of these trials have been mixed and patient population heterogeneous. CONCLUSION: The optimal dose, time to start, and duration of treatment for many appetite stimulants for cancer anorexia is still unknown. A more systematic approach to research methodology with universal outcome measure and prospective randomized studies are need. Combination regimens are needed but this cannot at the present time be supported by the data presented. |
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Authors:
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Tugba Yavuzsen; Mellar P Davis; Declan Walsh; Susan LeGrand; Ruth Lagman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: 23 ISSN: 0732-183X ISO Abbreviation: J. Clin. Oncol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-18 Completed Date: 2005-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 8500-11 Citation Subset: IM |
Affiliation:
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Harry R. Horvitz Center for Palliative Medicine, The Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Adult Anorexia / drug therapy*, etiology Antiemetics / therapeutic use* Appetite Stimulants / therapeutic use* Humans Metoclopramide / therapeutic use Neoplasms / complications* Progestins / therapeutic use Weight Loss / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antiemetics; 0/Appetite Stimulants; 0/Progestins; 364-62-5/Metoclopramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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