Document Detail

Systematic review of topical vasoconstrictors in endoscopic sinus surgery.
MedLine Citation:
PMID:  21271600     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The objective of this study is to systematically review the literature and examine the safety for the use of topical vasoconstrictors in endoscopic sinus surgery.
STUDY DESIGN: Systematic review clinical trials.
METHOD: A systematic literature search was performed in MEDLINE, EMBASE, The Cochrane Library, and National Guideline Clearinghouse, and references in the selected articles.
RESULTS: The search criteria captured 42 manuscripts with relevant titles. A systematic review on the topical use of phenylephrine was found; however, no other systematic review, meta-analyses, or clinical guidelines were identified. Six randomized clinical trials or comparative studies, as well as multiple case reports and review articles were also identified. The literature supports the safety of oxymetazoline and epinephrine when used judiciously in carefully selected patients undergoing endoscopic sinonasal surgery; however, topical phenylephrine is not recommended because of its risk profile.
CONCLUSION: In sinus or nasal surgery, topical vasoconstrictors should be used in a manner that minimizes the risk of cardiovascular morbidity.
Thomas S Higgins; Peter H Hwang; Todd T Kingdom; Richard R Orlandi; Heinz Stammberger; Joseph K Han
Publication Detail:
Type:  Journal Article     Date:  2011-01-13
Journal Detail:
Title:  The Laryngoscope     Volume:  121     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Department of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfok, Virginia, U.S.A.
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