Document Detail

Systematic review to support the development of nutrient reference intake values: challenges and solutions.
MedLine Citation:
PMID:  20504974     Owner:  NLM     Status:  MEDLINE    
Workshops sponsored by the Institute of Medicine (IOM) and the World Health Organization suggested that incorporating systematic (evidence) reviews into the process of updating nutrient reference values would provide a comprehensive and distilled evidence document to decision makers and enhance the transparency of the decision-making process the IOM used in recommending the Dietary Reference Intake values (DRIs) for US and Canadian populations. At the request of the US and Canadian government sponsors of the ongoing review of the 1997 vitamin D and calcium DRI values, the Tufts Evidence-based Practice Center performed a systematic review for the current DRI Committee to use early in its deliberations. We described the approach used to include systematic review into the IOM process for updating nutrient reference values and highlighted major challenges encountered along with the solutions used. The challenges stemmed from the need to review and synthesize a large number of primary studies covering a broad range of outcomes. We resolved these challenges by 1) working with a technical expert panel to prioritize and select outcomes of interest, 2) developing methods to use existing systematic reviews and documenting the limitations by doing so, 3) translating results from studies not designed to address issues of interest by using a transparent process, and 4) establishing tailored quality-assessment tools to assist in decision making. The experiences described in this article can serve as a basis for future improvements in systematic reviews of nutrients and to better integrate systematic review into development of future nutrient reference values.
Mei Chung; Ethan M Balk; Stanley Ip; Jounghee Lee; Teruhiko Terasawa; Gowri Raman; Thomas Trikalinos; Alice H Lichtenstein; Joseph Lau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2010-05-26
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  AIM; IM    
Tufts Evidence-based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA02111, USA.
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MeSH Terms
Calcium / administration & dosage
Evidence-Based Medicine*
Micronutrients / administration & dosage*
Nutrition Policy*
Reference Values
Review Literature as Topic*
United States
Vitamin D / administration & dosage
Grant Support
290-2007-10055-I//PHS HHS; U54 RR023562/RR/NCRR NIH HHS
Reg. No./Substance:
0/Micronutrients; 1406-16-2/Vitamin D; 7440-70-2/Calcium

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