Document Detail

Systematic review of the safety of topical corticosteroids in pregnancy.
MedLine Citation:
PMID:  20117858     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnant women may have skin conditions that require topical corticosteroids. However, little is known about their safety in pregnancy.
OBJECTIVE: We sought to evaluate the available evidence concerning the safety of topical corticosteroids in pregnancy.
METHODS: We systematically searched 17 databases and trial registers, and contacted pharmaceutical companies. Randomized controlled trials and cohort studies of topical corticosteroids in pregnant women, and case-control studies comparing maternal exposure to topical corticosteroids between patients and control subjects were included. The Newcastle-Ottawa Scale was used for quality assessment of included studies.
RESULTS: Seven studies, including two cohort and five case-control studies, were included. Most studies did not find significant associations of topical corticosteroids with congenital abnormality, preterm delivery stillbirth, and mode of delivery. One study found a significant association between first-trimester use of topical corticosteroids and orofacial cleft, and another study found a significant association between very potent topical corticosteroids and low birthweight.
LIMITATIONS: The available data were limited and mainly on orofacial cleft. The quality of evidence was generally low.
CONCLUSIONS: Currently limited and inconclusive data are unable to detect an association between topical corticosteroids and congenital abnormality, preterm delivery, or stillbirth. The current evidence shows no statistically significant difference between pregnant women who use and those who do not use topical corticosteroids. However, there does appear to be an association of very potent topical corticosteroids with low birthweight. Further cohort studies with comprehensive outcome measures, consideration of corticosteroid potency, dosage and indications, and a large sample size are needed.
Ching-Chi Chi; Shu-Hui Wang; Gudula Kirtschig; Fenella Wojnarowska
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-01
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  62     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-22     Revised Date:  2012-05-23    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-705     Citation Subset:  IM    
Copyright Information:
Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Department of Dermatology, Chang Gung Memorial Hospital-Chiayi, Chiayi, Taiwan.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Administration, Topical
Adrenal Cortex Hormones / adverse effects,  therapeutic use*
Clinical Trials as Topic
Fetal Diseases / chemically induced
Pregnancy Complications / drug therapy*
Skin Diseases / drug therapy*
Reg. No./Substance:
0/Adrenal Cortex Hormones
Comment In:
Arch Dermatol. 2012 Apr;148(4):525-7   [PMID:  22508878 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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