| Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. | |
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MedLine Citation:
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PMID: 21615439 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Factors other than acid may play a role in gastro-oesophageal reflux disease (GERD) and its complications. Aim To assessed the role of bile acids in the pathogenesis of GERD, Barrett's oesophagus and Barrett's-related neoplasia. Methods We conducted a systematic review of computerised bibliographic databases for original articles involving humans or human oesophageal tissue or cells that assessed exposure to or manipulation of bile acids. Outcomes assessed included GERD symptoms; gross oesophageal injury; Barrett's oesophagus and related neoplasia; and intermediate markers of inflammation, proliferation or neoplasia. Results Eighty-three original articles were included. In in vivo studies, bile acids concentrations were higher in the oesophageal aspirates of patients with GERD than controls, and bile acids infusions triggered GERD symptoms, especially in high concentrations or in combination with acid. In ex vivo/in vitro studies, bile acids stimulated squamous oesophageal cells and Barrett's epithelial cells to produce inflammatory mediators (e.g., IL-8 and COX-2) and caused oxidative stress, DNA damage and apoptosis. They also induced squamous cells to change their gene expression pattern to resemble intestinal-type cells and caused Barrett's cells to increase expression of intestinal-type genes. Conclusions In aggregate, these studies suggest that bile acids may contribute to the pathogenesis of symptoms, oesophagitis and Barrett's metaplasia with related carcinogenesis in patients with GERD. However, all study results are not uniform and substantial differences in study parameters may explain at least some of this variation. |
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Authors:
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K R McQuaid; L Laine; M B Fennerty; R Souza; S J Spechler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-25 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: - ISSN: 1365-2036 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, CA, USA. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Oregon Health and Science University, Portland, OR, USA. Veterans Affairs North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, TX, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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