| Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. | |
| | |
MedLine Citation:
|
PMID: 19847860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although the benefits of enteral nutrition in acute pancreatitis are well established, the optimal composition of enteral feeding is largely unknown. The aim of the study was to compare the tolerance and safety of enteral nutrition formulations in patients with acute pancreatitis. METHODS: Electronic databases (Scopus, MEDLINE, Cochrane Controlled Clinical Trials Register) and the proceedings of major pancreatology conferences were searched. RESULTS: Twenty randomized controlled trials, including 1070 patients, met the inclusion criteria. None of the following was associated with a significant difference in feeding intolerance: the use of (semi)elemental versus polymeric formulation (relative risk (RR) 0.62 (95 per cent confidence interval (c.i.) 0.10 to 3.97); P = 0.611); supplementation of enteral nutrition with probiotics (RR 0.69 (95 per cent c.i. 0.43 to 1.09); P = 0.110); or immunonutrition (RR 1.60 (95 per cent c.i. 0.31 to 8.29); P = 0.583). The risk of infectious complications and death did not differ significantly in any of the comparisons. CONCLUSION: The use of polymeric, compared with (semi)elemental, formulation does not lead to a significantly higher risk of feeding intolerance, infectious complications or death in patients with acute pancreatitis. Neither the supplementation of enteral nutrition with probiotics nor the use of immunonutrition significantly improves the clinical outcomes. |
| | |
Authors:
|
M S Petrov; B P T Loveday; R D Pylypchuk; K McIlroy; A R J Phillips; J A Windsor |
Publication Detail:
|
Type: Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The British journal of surgery Volume: 96 ISSN: 1365-2168 ISO Abbreviation: Br J Surg Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-27 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
|
Languages: eng Pagination: 1243-52 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, School of Medicine, University of Auckland, Auckland, New Zealand. max.petrov@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Dietary Fiber / administration & dosage, adverse effects Enteral Nutrition* Food, Formulated / adverse effects*, analysis Humans Pancreatitis / therapy* Publication Bias Randomized Controlled Trials as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors ...
Next Document: Pathogenesis of primary varicose veins.