Document Detail


Systematic review of the epidemiology of systemic lupus erythematosus in Asia-Pacific: Prevalence, incidence, clinical features and mortality.
MedLine Citation:
PMID:  22052624     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE.: Systemic lupus erythematosus (SLE), a chronic multisystem autoimmune disease with a wide spectrum of manifestations, shows considerable variation across the globe, although there is little evidence to indicate its relative prevalence in Asia. This review describes its prevalence, severity and outcome across countries in Asia-Pacific. METHODS.: A systematic literature search using three groups of terms: SLE, epidemiology and Asia-Pacific countries; of EMBASE and PubMed databases and non-English language resources: Chinese Wanfang, Korean KMbase, Korean College of Rheumatology, Japana Centra Revuo Medicina, Taiwan National Digital Library of Theses and Dissertations, and Taiwanese, Thai and Vietnamese journals. RESULTS.: The review showed considerable variation in SLE burden and survival rates across Asia-Pacific countries. Overall crude incidence rates (per 100,000 per year) ranged from 0.9-3.1 while crude prevalence rates ranged from 4.3-45.3 (per 100,000). Higher rates of renal involvement were observed for Asians (at diagnosis: 21-65% and over time: 40-82%) than for Caucasians, it being one of the main systems involved at death. While infections and active SLE were leading causes of death, a substantial proportion (6-40%) of deaths were due to cardiovascular involvement. The correlation between the Human Development Index and 5-year survival was 0.83. CONCLUSION.: This review highlights the need to closely monitor Asian SLE patients in Asian countries for renal and cardiovascular involvement especially those who may not be properly treated and are thus at greater risk of severe disease. We hope this will encourage further research specific to this region and lead to improved clinical management. © 2011 by the American College of Rheumatology.
Authors:
Rupert W Jakes; Sang-Cheol Bae; Worawit Louthrenoo; Chi-Chiu Mok; Sandra V Navarra; Namhee Kwon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-2
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Affiliation:
GlaxoSmithKline, Singapore. rupert.2.jakes@gsk.com.
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