Document Detail

Systematic review: endoscopic and imaging-based techniques in the assessment of portal haemodynamics and the risk of variceal bleeding.
MedLine Citation:
PMID:  19735231     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Invasive measurement of the hepatic venous pressure gradient (HVPG) is regarded as the gold standard for risk stratification and the evaluation of pharmaceutical agents in patients with portal hypertension.
AIM: To review the techniques for endoscopic and imaging-based assessment of portal haemodynamics, with particular emphasis on trials where the results were compared with HVPG or direct portal pressure measurement.
METHODS: Systematic search of the MEDLINE electronic database with keywords: portal hypertension, variceal bleeding, variceal pressure, endoscopic ultrasound, Doppler ultrasonography, magnetic resonance angiography, CT angiography, hepatic venous pressure gradient.
RESULTS: Computed tomography angiography and endoscopic ultrasound (EUS) have been both employed for the diagnosis of complications of portal hypertension and for the evaluation of the efficacy of endoscopic therapy. Colour Doppler ultrasonography and magnetic resonance angiography has given discrepant results. Endoscopic variceal pressure measurements either alone or combined with simultaneous EUS, correlate well with HVPG and risk of variceal bleeding and have a low interobserver variability.
CONCLUSIONS: Endoscopic and imaging-based measurements of portal haemodynamics provide an alternate means for the assessment of complications of portal hypertension. Further studies are required to validate their use in risk stratification and the evaluation of drug therapies in patients with portal hypertension.
S N Sgouros; K V Vasiliadis; S P Pereira
Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2009-09-04
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  30     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-04-16     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  965-76     Citation Subset:  IM    
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MeSH Terms
Endoscopy* / methods
Esophageal and Gastric Varices
Gastrointestinal Hemorrhage*
Hypertension, Portal / complications*,  diagnosis
Magnetic Resonance Angiography* / methods
Portal Pressure*
Portal System
Risk Factors
Ultrasonography, Doppler* / methods
Grant Support
G0801588//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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