Document Detail

Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome.
MedLine Citation:
PMID:  17233797     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to review systematically the available evidence on studies in humans on the effects of low-moderate levels of prenatal alcohol consumption (up to 10.4 UK units or 83 g/week) compared with consumption of no alcohol on pregnancy outcome. DESIGN: Systematic review. POPULATION: Pregnant women or women who are trying to become pregnant. METHODS: The search strategy included Medline, Embase, Cinahl and PsychInfo for the years 1970-2005. Titles and abstracts were read by two researchers and inclusion/exclusion being decided according to prespecified criteria. All the included articles were then obtained and read in full by the two researchers to decide on inclusion. The articles were assessed for quality using the Newcastle-Ottawa Quality Assessment Scales. MAIN OUTCOME MEASURES: Outcomes considered were miscarriage, stillbirth, intrauterine growth restriction, prematurity, birthweight, small for gestational age at birth and birth defects including fetal alcohol syndrome. RESULTS: The search resulted in 3630 titles and abstracts, which were narrowed down to 46 relevant articles. At low-moderate levels of consumption, there were no consistently significant effects of alcohol on any of the outcomes considered. Many of the reported studies had methodological weaknesses. CONCLUSIONS: This systematic review found no convincing evidence of adverse effects of prenatal alcohol exposure at low-moderate levels of exposure. However, weaknesses in the evidence preclude the conclusion that drinking at these levels during pregnancy is safe.
J Henderson; R Gray; P Brocklehurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-12
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  114     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-12     Revised Date:  2007-06-17    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-52     Citation Subset:  AIM; IM    
National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, UK.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Abortion, Spontaneous / chemically induced
Alcohol Drinking / adverse effects*
Fetal Growth Retardation / chemically induced
Pregnancy Outcome*
Premature Birth / chemically induced
Prenatal Exposure Delayed Effects*
Comment In:
BJOG. 2007 Jun;114(6):778-9; author reply 779   [PMID:  17516980 ]
Erratum In:
BJOG. 2007 Jul;114(7):914-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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