Document Detail

Systematic review of animal models for the study of implant integration, assessing the influence of material, surface and design.
MedLine Citation:
PMID:  22533945     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: The aim of this systematic review was to assess the scientific literature in terms of pre-clinical studies evaluating the influence of material, surface and design on the integration of an implant by hard and soft tissues. The included publications were analysed with regard to the frequency of reporting of criteria being derived from the ARRIVE guidelines. This served to trace elements within animal studies, where the quality of reporting needs to improve.
MATERIAL AND METHODS: The literature search was performed in Ovid Medline and included English literature from January 1990 to July 2011. A list of 24 criteria derived from the ARRIVE guidelines for animal research was adjusted to implant studies on osseointegration in pristine bone and was applied to all included study manuscripts. Each criteria was graded by "0" (not reported) or "1" (reported) and the frequency of reporting for each criteria was recorded.
RESULTS: A total of 271 studies were included into this review. Generally the quality of reporting increased with time. Low frequencies of reporting were achieved for criteria like "randomisation of animals", "reasons for the animal model" and "relevance to humans".
CONCLUSIONS: The frequency of reporting showed high percentages for most criteria. However, the quality of reporting in pre-clinical studies needs to improve in areas like the reporting of statistical information, study setup and the possible translation of the results to humans.
Bernd Stadlinger; Pedram Pourmand; Michael C Locher; Matthias C Schulz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  39 Suppl 12     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  28-36     Citation Subset:  D; IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, Zurich, Switzerland.
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