Document Detail

Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol.
MedLine Citation:
PMID:  18729847     Owner:  NLM     Status:  In-Data-Review    
Background  Screening colonoscopy exposes healthy patients to the risk of serious adverse events associated with bowel preparation. Randomized controlled trials are not an effective method for evaluating this risk. Aim  To search published literature in order to characterize the risk of adverse events associated with oral polyethylene glycol (PEG) or sodium phosphate (NaP). Methods  A systematic review identified case reports of any serious events associated with PEG or NaP. Reports to the Food and Drug Administration (FDA) were also examined. Results  Fifty-eight publications of significant events in 109 patients using NaP and 22 patients using PEG were identified. As the total number of prescriptions issued is unknown, rates for the two agents cannot be directly compared. Most commonly reported were electrolyte disturbances, renal failure and colonic ulceration for NaP and Mallory-Weiss tear, electrolyte disturbances and allergic reactions for PEG between January 2006 and December 2007; there were 171 cases of renal failure reported to the FDA following use of NaP and 10 following PEG. Conclusions  Adverse events following bowel preparation are uncommon, but potentially serious. Given that many of these patients are healthy individuals undergoing screening, the benefit/risk ratio must be carefully considered when deciding which preparation to prescribe in individual patients.
J Belsey; O Epstein; D Heresbach
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Publication Detail:
Type:  Journal Article     Date:  2008-08-24
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  29     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-28     Citation Subset:  IM    
Copyright Information:
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd.
JB Medical Ltd, The Old Brickworks, Sudbury Royal Free Hospital, Hampstead, London, UK Service des Maladies de l'Appareil Digestif, Centre Hospitalier Régional et Universitaire, 2 rue Henri le Guilloux, Rennes, France.
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