Document Detail

Systematic nocturnal atrial demand pacing results in high-output heart failure.
MedLine Citation:
PMID:  1601789     Owner:  NLM     Status:  MEDLINE    
Beat-to-beat parameters of heart rate (HR), intra-arterial blood pressure (BP), central venous pressure, and derived indexes of cardiac output and total peripheral resistance were recorded 18 h/day (from 1800 to 1200 h the following day) in four monkeys (Macaca mulatta) during 20 control days followed by 20 days of atrial demand pacing. The pacing rate was set at approximately 10 beats/min above the fastest hourly average HR recorded during the control period, i.e., sufficient to prevent the normal nocturnal fall in HR. Nocturnal pacing resulted in progressive weekly increases in central venous BP and arterial BP. Analyses of levels and diurnal trends in hemodynamic parameters and cardiac function curves across consecutive 5-day periods of nocturnal pacing revealed a hemodynamic pattern characteristic of high-output heart failure, which progressively increased (week by week) during the early morning hours (0500-0700). Sustained elevated left ventricular work resulting from the prevention of a nocturnal fall in HR may have been responsible for the reduction in cardiac function seen in this experimental model.
M I Talan; B T Engel; P H Chew
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-13     Completed Date:  1992-07-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1803-9     Citation Subset:  IM    
Laboratory of Behavioral Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224.
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MeSH Terms
Blood Pressure / physiology
Cardiac Output / physiology
Cardiac Output, High / etiology*,  physiopathology
Cardiac Pacing, Artificial / adverse effects*
Circadian Rhythm / physiology*
Heart Rate / physiology
Hemodynamics / physiology
Time Factors
Ventricular Function / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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