Document Detail


Systematic identification of pathways that couple cell growth and division in yeast.
MedLine Citation:
PMID:  12089449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms.
Authors:
Paul Jorgensen; Joy L Nishikawa; Bobby-Joe Breitkreutz; Mike Tyers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-06-27
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  297     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-08-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-400     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle
Cell Division*
Cell Nucleolus / metabolism
Crosses, Genetic
DNA-Binding Proteins / genetics,  physiology*
Epistasis, Genetic
Gene Deletion
Gene Expression Regulation, Fungal
Genes, Essential
Genes, Fungal*
Mutation
Oligonucleotide Array Sequence Analysis
Oxygen Consumption
Phenotype
Protein Kinases / genetics,  physiology
Ribosomes / metabolism*
Saccharomyces cerevisiae / cytology*,  genetics,  growth & development,  physiology*,  ultrastructure
Saccharomyces cerevisiae Proteins / biosynthesis,  genetics,  physiology*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Hct1 protein, S cerevisiae; 0/SFP1 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; EC 2.7.-/Protein Kinases; EC 2.7.1.-/SCH9 protein kinase
Comments/Corrections
Comment In:
Science. 2002 Jul 19;297(5580):351-2   [PMID:  12130772 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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