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Systematic characterization of amplitude-integrated EEG signals for monitoring the preterm brain.
MedLine Citation:
PMID:  23174705     Owner:  NLM     Status:  Publisher    
Background:In preterm infants the amplitude-integrated EEG (aEEG) is not established in clinical routine. The aim of this study was to derive normative data on aEEG parameters by means of longitudinal characterization and evaluating the impact of gestational age (GA), postnatal age (PNA), postmenstrual age (PMA), sedation and patent ductus arteriosus (PDA).Methods:Recordings from 61 infants with GA 28-31weeks were obtained during the first 72h, then weekly until the age of four weeks. Infants were divided into three groups: 1) no sedation, no PDA, 2) sedation, no PDA, 3) sedation, PDA. Assessed parameters included: background activity, cycling, amplitude and log ratio of the maximum/minimum amplitude.Results:GA and PNA had a significant impact within 72h. Sedation modified aEEG, presence of PDA was associated with reduced aEEG scores within 72h. The log ratio of the amplitude correlated with GA, but was unaffected by sedation and PDA.Conclusion:Evaluation of electrocortical background activity within the first postnatal hours and longitudinally over days and weeks is important, to better understand postnatal factors impacting cerebral function in preterm infants. There is a need to agree on definitions and a standardized reporting system in order to permit comparisons between studies and establish aEEG as method for routine monitoring of preterm infants.Pediatric Research (2012); doi:10.1038/pr.2012.171.
Elke Griesmaier; David Pierre Enot; Miriam Bachmann; Vera Neubauer; Lena Hellström-Westas; Ursula Kiechl-Kohlendorfer; Matthias Keller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-22
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics II, Medical University of Innsbruck, Innsbruck, Austria.
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