Document Detail


Systematic analysis of the insulinotropic and glucagonotropic potency of saturated and monounsaturated fatty acid mixtures in rat pancreatic islets.
MedLine Citation:
PMID:  17611899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Blood contains a mixture of different fatty acids (FFAs) with palmitate and oleate as major components whose molar ratio is dependent on dietary habits. Based on the theory of lipotoxicity for the development of type 2 diabetes such variances in the FFA composition might interfere with lipotoxic effects on the endocrine pancreas. METHODS: Using different ratios of FFA mixtures with palmitate and oleate, we have looked at FFA specific effects on the secretion of mature insulin and glucagon in isolated rat pancreatic islets. RESULTS: The insulinotropic potency of the oleate dominated FFA solutions was stronger than that of the palmitate dominated FFA mixtures. Conversely, the glucagonotropic potency was stronger in the palmitate dominated FFA mixtures. Palmitate and oleate similarly contributed to an impaired release of mature insulin at 16.7 mM of glucose. CONCLUSION: Based on the present IN VITRO data, FFA specific differences in terms of glucagonotropic and insulinotropic potency appear rather slight. For the IN VIVO situation, it may be assumed that the dietary influence of saturated and monounsaturated fatty acids on hyperproinsulinemia or hyperglucagonemia are rather secondary for the development of type 2 diabetes.
Authors:
C E Wrede; R Buettner; H Wobser; I Ottinger; L C Bollheimer
Related Documents :
1243089 - The effect of brocresine (nsd-1055) on basal and stimulated gastric acid secretion in c...
1932479 - Inhibition of gastrin- and histamine-stimulated gastric acid secretion by gastrin and c...
894139 - Lipids of the anal sac secretions of the red fox, vulpes vulpes and of the lion, panthe...
1968679 - Salicylazosulfapyridine (salazopyrin) effect on endotoxin-induced production of interle...
1188309 - The effect of beta-adrenergic blockade upon basal and pentagastrin-stimulated gastric a...
7128959 - Postprandial acid secretion and serum gastrin response before and after exclusion of th...
15066659 - Evaluation of the antibacterial efficacy of diesters of azelaic acid.
3106549 - Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide ...
8931939 - Phosphatase inhibitors--iii. benzylaminophosphonic acids as potent inhibitors of human ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  39     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-05     Completed Date:  2007-09-27     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  482-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
C-Peptide / secretion
Fatty Acids, Monounsaturated / pharmacology*
Glucagon / secretion*
Humans
Insulin / secretion*
Islets of Langerhans / drug effects*,  secretion*
Male
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/C-Peptide; 0/Fatty Acids, Monounsaturated; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of beta-endorphin imprinting during late pregnancy on the brain serotonin and plasma nocistat...
Next Document:  Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver.