| A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. | |
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MedLine Citation:
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PMID: 20146558 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In this article, we systematically review the available pre-clinical research on such neuroprotective therapies that are administered in a non-invasive manner for acute SCI. Specifically, we review treatments that have a relatively high potential for translation due to the fact that they are already used in human clinical applications, or are available in a form that could be administered to humans. These include: erythropoietin, NSAIDs, anti-CD11d antibodies, minocycline, progesterone, estrogen, magnesium, riluzole, polyethylene glycol, atorvastatin, inosine, and pioglitazone. The literature was systematically reviewed to examine studies in which an in-vivo animal model was utilized to assess the efficacy of the therapy in a traumatic SCI paradigm. Using these criteria, 122 studies were identified and reviewed in detail. Wide variations exist in the animal species, injury models, and experimental designs reported in the pre-clinical literature on the therapies reviewed. The review highlights the extent of investigation that has occurred in these specific therapies, and points out gaps in our knowledge that would be potentially valuable prior to human translation. |
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Authors:
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Brian K Kwon; Elena Okon; Jessica Hillyer; Cody Mann; Darryl Baptiste; Lynne C Weaver; Michael G Fehlings; Wolfram Tetzlaff |
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Publication Detail:
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Type: Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: Journal of neurotrauma Volume: 28 ISSN: 1557-9042 ISO Abbreviation: J. Neurotrauma Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: United States |
Other Details:
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Languages: eng Pagination: 1545-88 Citation Subset: IM |
Affiliation:
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1 University of British Columbia , Combined Neurosurgical and Orthopaedic Spine Program (CNOSP), Department of Orthopaedics, Vancouver, British Columbia, Canada . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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