Document Detail

Systematic Review and Meta-analysis on Non-classic Cardiovascular Biomarkers after Hypertensive Pregnancy Disorders.
MedLine Citation:
PMID:  24637129     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The aim of this study is to investigate which non-classic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared to women with uncomplicated pregnancies.
STUDY DESIGN: Systematic review and meta-analysis of observational studies. A search was performed in PubMed, Embase, Cochrane and Cinahl including articles from inception to 27 February 2013. Included were cohort studies and case-control studies. Cases were women with a history of hypertension in pregnancy, control subjects were women with a history of uncomplicated pregnancies. Of the 3136 found, 21 studies on 16 non-classic cardiovascular biomarkers are described in this review; 12 studies on 5 biomarkers were included in the meta-analysis.
RESULTS: Women with a history of hypertensive pregnancy disorders had a higher homocysteine level compared to women with a history of uncomplicated pregnancies (5 studies; pooled mean difference 0.77ng/ml; 95% confidence interval 0.27 to 1.26; p <0.01). For the other non-classic cardiovascular biomarkers including markers in areas of inflammation, thrombosis and angiogenesis, we found no significant differences.
CONCLUSION: This review and meta-analysis showed that women with a history of hypertensive pregnancy disorders have higher homocysteine levels compared to women with a history of uncomplicated pregnancies. These data suggest persistent endothelial alteration after pregnancies complicated by hypertensive disorders.
Sanne Visser; Wietske Hermes; Johannes C F Ket; René H J Otten; Maria G Van Pampus; Kitty W M Bloemenkamp; Arie Franx; Ben W Mol; Christianne J M DE Groot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-14
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Mosby, Inc. All rights reserved.
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