Document Detail

A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants.
MedLine Citation:
PMID:  22814228     Owner:  NLM     Status:  Publisher    
Background: Births between 37 0/7 and 38 6/7 weeks of gestation are newly defined as early term infants (ETIs), and are increasingly considered to be at higher risk of adverse outcomes than infants born at 39-41 weeks' gestation. To date, the long-term development of ETIs has not been systematically reviewed. Objective: To assess the effect of being born early term on long-term developmental outcomes. Methods: The literature of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials, and abstracts from the Society of Pediatric Research were searched. If two or more studies regarding the same outcome were retrieved, a meta-analysis was conducted by RevMan 5. A sensitivity analysis was performed to assess the heterogeneity. Results: Eleven studies involving 4 categories of long-term development were included. Compared with infants born at 39-41 weeks' gestation, ETIs had poorer outcomes in school performance, neurodevelopment, behavior and emotional status and long-term social outcomes. Meta-analyses showed that being born early term significantly increased the risk of cerebral palsy [relative risk, RR, 1.75 (95% confidence interval, CI, 1.32, 2.31)] and mathematical difficulties [RR 1.13 (95% CI 1.04, 1.21)]. The statistical test of heterogeneity for cerebral palsy was significant. Sensitivity analysis demonstrated that variations in follow-up periods were associated with heterogeneity. Conclusion: Emerging evidence suggests that ETIs are at risk of adverse long-term outcomes. Due to paucity and heterogeneity of the existing data, future research is needed to clarify the long-term risk of being born early term.
Ying Dong; Shao-Jie Chen; Jia-Lin Yu
Related Documents :
22889398 - Preverbal infants infer intentional agents from the perception of regularity.
22305678 - Pneumococcal polysaccharide vaccine at 12 months of age produces functional immune resp...
22570968 - Bilateral bloody nipple discharge in a male infant: sonographic findings and proposed d...
3977388 - Deaths in cots are not always cot deaths.
24550698 - The effect of maternal stress activation on the offspring during lactation in light of ...
11035318 - Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-14
Journal Detail:
Title:  Neonatology     Volume:  102     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  212-221     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and Disroders, Chongqing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer ...
Next Document:  Effects of Chronic Social Isolation on Wistar Rat Behavior and Brain Plasticity Markers.