| A systematic review of medical treatments for children with autism spectrum disorders. | |
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MedLine Citation:
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PMID: 21464191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Many medical treatments for ASDs have been proposed and studied, but there is currently no consensus regarding which interventions are most effective. OBJECTIVE: To systematically review evidence regarding medical treatments for children aged 12 years and younger with ASDs. METHODS: We searched the Medline, PsycInfo, and ERIC (Education Resources Information Center) databases from 2000 to May 2010, regulatory data for approved medications, and reference lists of included articles. Two reviewers independently assessed each study against predetermined inclusion/exclusion criteria. Studies of secretin were not included in this review. Two reviewers independently extracted data regarding participant and intervention characteristics, assessment techniques, and outcomes and assigned overall quality and strength-of-evidence ratings on the basis of predetermined criteria. RESULTS: Evidence supports the benefit of risperidone and aripiprazole for challenging and repetitive behaviors in children with ASDs. Evidence also supports significant adverse effects of these medications. Insufficient strength of evidence is present to evaluate the benefits or adverse effects for any other medical treatments for ASDs, including serotonin-reuptake inhibitors and stimulant medications. CONCLUSIONS: Although many children with ASDs are currently treated with medical interventions, strikingly little evidence exists to support benefit for most treatments. Risperidone and aripiprazole have shown benefit for challenging and repetitive behaviors, but associated adverse effects limit their use to patients with severe impairment or risk of injury. |
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Authors:
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Melissa L McPheeters; Zachary Warren; Nila Sathe; Jennifer L Bruzek; Shanthi Krishnaswami; Rebecca N Jerome; Jeremy Veenstra-Vanderweele |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-04-04 |
Journal Detail:
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Title: Pediatrics Volume: 127 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-07-11 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e1312-21 Citation Subset: AIM; IM |
Affiliation:
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465 21st Ave S, 7158 Medical Research Building III, Nashville, TN 37232, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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administration & dosage*,
adverse effects Child Child Development Disorders, Pervasive / diagnosis*, drug therapy* Child, Preschool Citalopram / administration & dosage, adverse effects Dose-Response Relationship, Drug Drug Administration Schedule Evidence-Based Medicine Female Fluoxetine / administration & dosage, adverse effects Humans Male Patient Compliance Piperazines / administration & dosage*, adverse effects Prognosis Quinolones / administration & dosage*, adverse effects Randomized Controlled Trials as Topic Risperidone / administration & dosage*, adverse effects Serotonin Antagonists / administration & dosage, adverse effects Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Piperazines; 0/Quinolones; 0/Serotonin Antagonists; 106266-06-2/Risperidone; 129722-12-9/aripiprazole; 54910-89-3/Fluoxetine; 59729-33-8/Citalopram |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2011 Nov;159(5):872-3
[PMID:
21996118
]
Evid Based Ment Health. 2011 Nov;14(4):105 [PMID: 21963708 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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