| Systematic Review of Measurement and Adjustment for Colonization Pressure in Studies of Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and Clostridium difficile Acquisition. | |
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MedLine Citation:
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PMID: 21515979 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. Colonization pressure is an important infection control metric. The aim of this study was to describe the definition and measurement of and adjustment for colonization pressure in nosocomial-acquisition risk factor studies of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and Clostridium difficile. Methods. We performed a computerized search of studies of nosocomial MRSA, VRE, and C. difficile acquisition published before July 1, 2009, through MEDLINE. Studies were included if a study outcome was MRSA, VRE, or C. difficile acquisition; the authors identified risk factors associated with MRSA, VRE, or C. difficile acquisition; and the study measured colonization pressure. Results. The initial MEDLINE search yielded 505 articles. Sixty-six of these were identified as studies of nosocomial MRSA, VRE, or C. difficile acquisition; of these, 18 (27%) measured colonization pressure and were included in the final review. The definition of colonization pressure varied considerably between studies: the proportion of MRSA- or VRE-positive patients (5 studies), the proportion of MRSA- or VRE-positive patient-days (6 studies), or the total or mean number of MRSA-, VRE-, or C. difficile-positive patients or patient-days (7 studies) in the unit over periods of varying length. In 10 of 13 studies, colonization pressure was independently associated with MRSA, VRE, or C. difficile acquisition. Conclusion. There is a need for a simple and consistent method to quantify colonization pressure in both research and routine clinical care to accurately assess the effect of colonization pressure on cross-transmission of antibiotic-resistant bacteria. |
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Authors:
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Adebola O Ajao; Anthony D Harris; Mary-Claire Roghmann; J Kristie Johnson; Min Zhan; Jessina C McGregor; Jon P Furuno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America Volume: 32 ISSN: 1559-6834 ISO Abbreviation: Infect Control Hosp Epidemiol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804099 Medline TA: Infect Control Hosp Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 481-9 Citation Subset: IM; N |
Affiliation:
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Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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