Document Detail


A systematic review of directly applied biologic therapies for acute spinal cord injury.
MedLine Citation:
PMID:  20082560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In this article, we systematically reviewed the available preclinical research on such neuroprotective therapies that are administered in a non-invasive manner for acute SCI. Specifically, we reviewed treatments that have a relatively high potential for translation due to the fact that they are already used in human clinical applications or are available in a form that could be administered to humans. These included: erythropoietin, NSAIDs, anti-CD11d antibodies, minocycline, progesterone, estrogen, magnesium, riluzole, polyethylene glycol, atorvastatin, inosine, and pioglitazone. The literature was systematically reviewed to examine studies in which an in vivo animal model was utilized to assess the efficacy of the therapy in a traumatic spinal cord injury paradigm. Using these criteria, 122 studies were identified and reviewed in detail. Wide variations exist in the animal species, injury models, and experimental designs reported in the preclinical literature on the therapies reviewed. The review highlights the extent of investigation that has occurred in these specific therapies, and points out gaps in our knowledge that would be potentially valuable prior to human translation.
Authors:
Brian K Kwon; Elena B Okon; Ward Plunet; Darryl Baptiste; Karim Fouad; Jessica Hillyer; Lynne C Weaver; Michael G Fehlings; Wolfram Tetzlaff
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-16
Journal Detail:
Title:  Journal of neurotrauma     Volume:  28     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-26     Completed Date:  2011-12-08     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1589-610     Citation Subset:  IM    
Affiliation:
Combined Neurosurgical and Orthopaedic Spine Program, Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada. brian.kwon@vch.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / therapeutic use*
Disease Models, Animal
Humans
Myelin Proteins / antagonists & inhibitors
Spinal Cord Injuries / drug therapy*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Myelin Proteins; 0/Nogo protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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