Document Detail

A Systematic Review of the Association between Pulmonary Tuberculosis and the Development of Chronic Airflow Obstruction in Adults.
MedLine Citation:
PMID:  23652030     Owner:  NLM     Status:  Publisher    
Background: Chronic obstructive pulmonary disease (COPD) is a major public health concern, accounting for 3 million deaths annually, 90% of which occur in low- and middle-income countries. Pulmonary tuberculosis (PTB) as a contributory factor in the aetiology of COPD is under debate, with most epidemiologic evidence suggesting a positive association. Objectives: To compile a systematic review of evidence for an association between PTB and the development of chronic airflow obstruction (CAO). Methods: We performed a systematic review of original English-language, peer-reviewed literature using the PubMed/MEDLINE database. CAO was defined by spirometry [FEV1:FVC ratio <0.70 or <LLN (lower limit of normal) for age]. Results: Nineteen studies (1 case series, 3 case-control studies, 4 cohort studies, 8 single-centre cross-sectional studies and 3 multi-centre cross-sectional studies) met the eligibility criteria. All but 2 reported a positive association between PTB and CAO. Three of 4 large population-based surveys (n = 4,291-8,066) confirmed a significant association between PTB and CAO (OR 1.37 - 2.94). A formal meta-analysis was not possible owing to marked heterogeneity between studies. Conclusions: This systematic review confirms evidence for a positive association between a past history of tuberculosis and the presence of CAO. The association is independent of cigarette smoking. Causality is likely but cannot be assumed.
Brian W Allwood; Landon Myer; Eric D Bateman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-03
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  -     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Lung Institute, University of Cape Town, Cape Town, South Africa.
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