| Systematic mapping of the monkey inferior colliculus reveals enhanced low frequency sound representation. | |
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MedLine Citation:
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PMID: 21307328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the functional architecture of the inferior colliculus (IC) in rhesus monkeys. We systematically mapped multiunit responses to tonal stimuli and noise in the IC and surrounding tissue of six rhesus macaques, collecting data at evenly placed locations and recording nonresponsive locations to define boundaries. The results show a modest tonotopically organized region (17 of 100 recording penetration locations in 4 of 6 monkeys) surrounded by a large mass of tissue that, although vigorously responsive, showed no clear topographic arrangement (68 of 100 penetration locations). Rather, most cells in these recordings responded best to frequencies at the low end of the macaque auditory range. The remaining 15 (of 100) locations exhibited auditory responses that were not sensitive to sound frequency. Potential anatomical correlates of functionally defined regions and implications for midbrain auditory prosthetic devices are discussed. |
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Authors:
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David A Bulkin; Jennifer M Groh |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-09 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 105 ISSN: 1522-1598 ISO Abbreviation: J. Neurophysiol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-09-29 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1785-97 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Duke University, Durham, NC 27708, USA. bulkin@cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods* Animals Auditory Pathways / physiology Auditory Threshold / physiology* Brain Mapping / methods* Electrodes Female Inferior Colliculi / physiology* Macaca mulatta / physiology* Male Models, Animal Sensory Receptor Cells / physiology Sound* |
| Grant Support | |
ID/Acronym/Agency:
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DC-010294/DC/NIDCD NIH HHS; EY-016478/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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