| A Systematic Literature Review of Cerebrospinal Fluid Biomarkers in Delirium. | |
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MedLine Citation:
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PMID: 21876357 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology. Methods: A systematic literature review of CSF studies of DSM or ICD delirium was performed. Results: In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, β-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features. Conclusions: No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies. |
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Authors:
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Roanna J Hall; Susan D Shenkin; Alasdair M J Maclullich |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-26 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 32 ISSN: 1421-9824 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: - |
Other Details:
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Languages: ENG Pagination: 79-93 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Edinburgh Delirium Research Group, Geriatric Medicine, Division of Health Sciences, School of Clinical Sciences and Community Health, Edinburgh, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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