Document Detail


A systematic literature review of cerebrospinal fluid biomarkers in delirium.
MedLine Citation:
PMID:  21876357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology.
METHODS: A systematic literature review of CSF studies of DSM or ICD delirium was performed.
RESULTS: In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, β-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features.
CONCLUSIONS: No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies.
Authors:
Roanna J Hall; Susan D Shenkin; Alasdair M J Maclullich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-26
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  32     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-02-27     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  79-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / cerebrospinal fluid
Biological Markers / cerebrospinal fluid*
Brain / metabolism*,  physiopathology
Delirium / cerebrospinal fluid*,  diagnosis
Dopamine / cerebrospinal fluid
Humans
Hydrocortisone / cerebrospinal fluid
Interleukin-8 / cerebrospinal fluid
Lactic Acid / cerebrospinal fluid
Phosphopyruvate Hydratase / cerebrospinal fluid
Prognosis
Somatostatin / cerebrospinal fluid
beta-Endorphin / cerebrospinal fluid
Grant Support
ID/Acronym/Agency:
G108/646//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-8; 33X04XA5AT/Lactic Acid; 51110-01-1/Somatostatin; 60617-12-1/beta-Endorphin; EC 3.1.1.7/Acetylcholinesterase; EC 4.2.1.11/Phosphopyruvate Hydratase; VTD58H1Z2X/Dopamine; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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