Document Detail

A systematic correlation between morphology and functional alterations in diabetic macular edema.
MedLine Citation:
PMID:  20484587     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to correlate different types of retinal morphologic alterations secondary to diabetic macular disease with their characteristic impact on retinal function.
METHODS: In the present cross-sectional study, 26 eyes of 26 diabetic patients with clinically significant macular edema were examined. All patients underwent complete standardized ophthalmologic examination, including SD-OCT and microperimetry. Microperimetric values were projected over the scanning laser ophthalmoscope image of the OCT device, allowing direct correlation of functional and morphologic parameters. Results over all 1066 individual areas were analyzed using a general linear model.
RESULTS: All the characteristic morphologic alterations demonstrated a significant effect on retinal function (P < 0.0002), except for outer nuclear layer (ONL) hyporeflectivity and small ONL cysts. Large ONL cysts (>220 μm) and serous retinal detachment had the greatest estimated negative effect on retinal sensitivity (-3.86 and -3.66 dB), followed by medium-sized ONL cysts, hard exudates associated with an extinction of the scan signal, and inner nuclear layer cysts.
CONCLUSIONS: In diabetic macular edema, serous retinal detachment and large ONL cysts are the two morphologic changes with the greatest negative impact on retinal function.
Gábor György Deák; Matthias Bolz; Markus Ritter; Sonja Prager; Thomas Benesch; Ursula Schmidt-Erfurth;
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Publication Detail:
Type:  Journal Article     Date:  2010-05-19
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  51     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6710-4     Citation Subset:  IM    
Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Cross-Sectional Studies
Cysts / etiology,  pathology*
Diabetes Mellitus, Type 2 / complications
Diabetic Retinopathy / complications,  physiopathology*
Macular Edema / etiology,  physiopathology*
Middle Aged
Prospective Studies
Retina / physiopathology*
Retinal Detachment / etiology,  pathology*
Subretinal Fluid
Tomography, Optical Coherence
Visual Field Tests
Visual Fields

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