Document Detail


System-level biomechanical approach for the evaluation of term and preterm pregnancy maintenance.
MedLine Citation:
PMID:  23445054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm birth is the primary contributor to perinatal morbidity and mortality, with those born prior to 32 weeks disproportionately contributing compared to those born at 32-37 weeks. Outcomes for babies born prematurely can be devastating. Parturition is recognized as a mechanical process that involves the two processes that are required to initiate labor: rhythmic myometrial contractions and cervical remodeling with subsequent dilation. Studies of parturition tend to separate these two processes rather than evaluate them as a unified system. The mechanical property characterization of the cervix has been primarily performed on isolated cervical tissue, with an implied understanding of the contribution from the uterine corpus. Few studies have evaluated the function of the uterine corpus in the absence of myometrial contractions or in relationship to retaining the fetus. Therefore, the cervical-uterine interaction has largely been neglected in the literature. We suggest that a system-level biomechanical approach is needed to understand pregnancy maintenance. To that end, this paper has two main goals. One goal is to highlight the gaps in current knowledge that need to be addressed in order to develop any comprehensive and clinically relevant models of the system. The second goal is to illustrate the utility of finite element models in understanding pregnancy maintenance of the cervical-uterine system. The paper targets an audience that includes the reproductive biologist/clinician and the engineer/physical scientist interested in biomechanics and the system level behavior of tissues.
Authors:
Hussam Mahmoud; Amy Wagoner Johnson; Edward K Chien; Michael J Poellmann; Barbara McFarlin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  135     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-28     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  021009     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biomechanical Phenomena
Cervix Uteri / cytology,  pathology,  physiology,  physiopathology
Female
Finite Element Analysis
Humans
Materials Testing
Mechanical Processes*
Models, Biological
Pregnancy
Premature Birth* / pathology,  physiopathology
Term Birth*
Grant Support
ID/Acronym/Agency:
5R21HD058705/HD/NICHD NIH HHS; R21 HD058705/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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