Document Detail

Syringometaplasia: mucinous and squamous variants.
MedLine Citation:
PMID:  500875     Owner:  NLM     Status:  MEDLINE    
The eccrine sweat ducts are normally lined by cuboidal epithelial cells which may rarely undergo metaplasia, i.e. syringometaplasia. Two lesions were observed in which eccrine sweat ducts displayed the mucinous and squamous variants of syringometaplasia. The first lesion clinically and histologically appeared to be a plantar wart. Microscopically, it consisted of a central invagination surrounded by marked epidermal acanthosis and hyperkeratosis. The invagination was lined by keratinocytes admixed with mucin-filled goblet cells. The mucin was positive by the Alcian blue (pH 2.5) and mucicarmine stains. Numerous eccrine sweat ducts led into the invagination and were focally lined by the mucin-laden cells. Recognition of mucinous syringometaplasia is important since it may be confused with primary or metastatic adenocarcinoma of the skin. The second lesion occurred on the outer ear and was clinically believed to be chondrodermatitis nodularis helicis. Microscopically, there were many islands of atypical squamous cells within the papillary and reticular dermis. These epithelial islands represented squamous syringometaplasia since many contained central lumina with eosinophilic cuticles and blended with normal ductal structures. It is important not to confuse this metaplastic change with invasive squamous cell carcinoma. Squamous syringometaplasia may be analogous to necrotizing sialometaplasia, a recently described phenomenon which occurs in minor salivary glands.
D T King; R J Barr
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  6     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  284-91     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / pathology
Diagnosis, Differential
Eccrine Glands* / pathology
Keratosis / pathology
Middle Aged
Skin / pathology
Skin Neoplasms / pathology
Sweat Gland Diseases / pathology
Sweat Glands* / pathology
Warts / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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