Document Detail


A Syrian golden hamster model recapitulating ebola hemorrhagic fever.
MedLine Citation:
PMID:  23045629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or vaccine is currently available. While the nonhuman primate (NHP) model is used for final evaluation of experimental vaccines and therapeutic efficacy, rodent models have been widely used in ebolavirus research because of their convenience. However, the validity of rodent models has been questioned given their low predictive value for efficacy testing of vaccines and therapeutics, a result of the inconsistent manifestation of coagulopathy seen in EHF. Here, we describe a lethal Syrian hamster model of EHF using mouse-adapted Ebola virus. Infected hamsters displayed most clinical hallmarks of EHF, including severe coagulopathy and uncontrolled host immune responses. Thus, the hamster seems to be superior to the existing rodent models, offering a better tool for understanding the critical processes in pathogenesis and providing a new model for evaluating prophylactic and postexposure interventions prior to testing in NHPs.
Authors:
Hideki Ebihara; Marko Zivcec; Donald Gardner; Darryl Falzarano; Rachel LaCasse; Rebecca Rosenke; Dan Long; Elaine Haddock; Elizabeth Fischer; Yoshihiro Kawaoka; Heinz Feldmann
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural     Date:  2012-10-08
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  207     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-02-28     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-18     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Coagulation
Cercopithecus aethiops
Cricetinae
Disease Models, Animal*
Disseminated Intravascular Coagulation
Ebolavirus / pathogenicity*
Hemorrhagic Fever, Ebola / immunology,  mortality,  physiopathology*,  virology
Humans
Male
Mesocricetus*
Mice
Vero Cells
Grant Support
ID/Acronym/Agency:
ZIA AI001089-01/AI/NIAID NIH HHS
Comments/Corrections

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