| A Syrian golden hamster model recapitulating ebola hemorrhagic fever. | |
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MedLine Citation:
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PMID: 23045629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or vaccine is currently available. While the nonhuman primate (NHP) model is used for final evaluation of experimental vaccines and therapeutic efficacy, rodent models have been widely used in ebolavirus research because of their convenience. However, the validity of rodent models has been questioned given their low predictive value for efficacy testing of vaccines and therapeutics, a result of the inconsistent manifestation of coagulopathy seen in EHF. Here, we describe a lethal Syrian hamster model of EHF using mouse-adapted Ebola virus. Infected hamsters displayed most clinical hallmarks of EHF, including severe coagulopathy and uncontrolled host immune responses. Thus, the hamster seems to be superior to the existing rodent models, offering a better tool for understanding the critical processes in pathogenesis and providing a new model for evaluating prophylactic and postexposure interventions prior to testing in NHPs. |
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Authors:
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Hideki Ebihara; Marko Zivcec; Donald Gardner; Darryl Falzarano; Rachel LaCasse; Rebecca Rosenke; Dan Long; Elaine Haddock; Elizabeth Fischer; Yoshihiro Kawaoka; Heinz Feldmann |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural Date: 2012-10-08 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 207 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-31 Completed Date: 2013-02-28 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 306-18 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NID), Rocky Mountain Laboratories (RML), Hamilton, Montana 59840, USA. ebiharah@niaid.nih.gov |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Cercopithecus aethiops Cricetinae Disease Models, Animal* Disseminated Intravascular Coagulation Ebolavirus / pathogenicity* Hemorrhagic Fever, Ebola / immunology, mortality, physiopathology*, virology Humans Male Mesocricetus* Mice Vero Cells |
| Grant Support | |
ID/Acronym/Agency:
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ZIA AI001089-01/AI/NIAID NIH HHS |
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