| α-Synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexanoic acid in a mouse model for Parkinson's disease. | |
| | |
MedLine Citation:
|
PMID: 21929559 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
α-synuclein (α-Syn) is a neuronal protein that accumulates progressively in Parkinson's disease and related synucleinopathies. Attempting to identify cellular factors that affect α-Syn neuropathology, we previously reported that polyunsaturated fatty acids (PUFAs) promote α-Syn oligomerization and aggregation in cultured cells. We now report that docosahexaenoic acid (DHA) a 22:6 PUFA affects α-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor γ2 (PPARγ2). In addition, we show that dietary changes in brain DHA levels affect α-Syn cytopathology in mice transgenic for the Parkinson's disease-causing A53T mutation in human α-Syn. A diet enriched in docosahexaenoic acid, an activating ligand of RXR, increased the accumulation of soluble and insoluble neuronal α-Syn, neuritic injury and astrocytosis. Conversely, abnormal accumulations of α-Syn and its deleterious effects were significantly attenuated by low dietary docosahexaenoic acid levels. Our results suggest a role for activated RXR/PPARγ 2, obtained by elevated brain polyunsaturated fatty acids levels, in α-Syn neuropathology. |
| | |
Authors:
|
Eugenia Yakunin; Virginie Loeb; Haya Kisos; Yoav Biala; Shlomo Yehuda; Yoel Yaari; Dennis J Selkoe; Ronit Sharon |
Related Documents
:
|
9620589 - Apparent paralytic shellfish poisoning in captive herring gulls fed commercial scallops. 467569 - The occurrence of lipid droplets in the proximal and distal tubules of the rat kidney a... 1547769 - Phenytoin-folate interactions: differing effects of the sodium salt and the free acid o... 16479949 - Egg storage period and weight effects on hatchability of ostrich (struthio camelus) eggs. 16173789 - Synthesis and biological evaluation of diethylenetriamine pentaacetic acid-polyethylene... 2585449 - Species recognition elicited by differences in composition of the genital sex pheromone... 2387779 - Amikacin analogs with a fluorinated amino acid side chain. 8982669 - Effect of pentacaine and its derivatives on the contractile responses of smooth muscle ... 16805949 - In-vitro transcutaneous delivery of ketoprofen and polyunsaturated fatty acids from a p... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-20 |
Journal Detail:
|
Title: Brain pathology (Zurich, Switzerland) Volume: - ISSN: 1750-3639 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9216781 Medline TA: Brain Pathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors; Brain Pathology © 2011 International Society of Neuropathology. |
Affiliation:
|
Department of Biochemistry and Molecular Biology and Medical Neurobiology, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Sha'ari Mishpat College, Hod HaSharon, Israel. Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiologic Features of Granulomatous Mastitis.
Next Document: Genetic re-identification and antifungal susceptibility testing of Aspergillus section Nigri strains...