Document Detail


Synthetic pulmonary surfactant preparations: new developments and future trends.
MedLine Citation:
PMID:  18288994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary surfactant is a lipid-protein complex that coats the interior of the alveoli and enables the lungs to function properly. Upon its synthesis, lung surfactant adsorbs at the interface between the air and the hypophase, a capillary aqueous layer covering the alveoli. By lowering and modulating surface tension during breathing, lung surfactant reduces respiratory work of expansion, and stabilises alveoli against collapse during expiration. Pulmonary surfactant deficiency, or dysfunction, contributes to several respiratory pathologies, such as infant respiratory distress syndrome (IRDS) in premature neonates, and acute respiratory distress syndrome (ARDS) in children and adults. The main clinical exogenous surfactants currently in use to treat some of these pathologies are essentially organic extracts obtained from animal lungs. Although very efficient, natural surfactants bear serious defects: i) they could vary in composition from batch to batch; ii) their production involves relatively high costs, and sources are limited; and iii) they carry a potential risk of transmission of animal infectious agents and the possibility of immunological reaction. All these caveats justify the necessity for a highly controlled synthetic material. In the present review the efforts aimed at new surfactant development, including the modification of existing exogenous surfactants by adding molecules that can enhance their activity, and the progress achieved in the production of completely new preparations, are discussed.
Authors:
Ismael Mingarro; Dunja Lukovic; Marçal Vilar; Jesús Pérez-Gil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  15     ISSN:  0929-8673     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-21     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  393-403     Citation Subset:  IM    
Affiliation:
Departament de Bioquímica i Biologia Molecular, Universitat de València, E-46 100 Burjassot, Spain. Ismael.Mingarro@uv.es
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Humans
Lipids / chemistry
Models, Molecular
Molecular Sequence Data
Pulmonary Surfactants / chemical synthesis,  chemistry*,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Lipids; 0/Pulmonary Surfactants

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