Document Detail


Synthetic octapeptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn promotes differentiation in promyelocytic HL-60 cell line.
MedLine Citation:
PMID:  7549788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of the octapeptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn in the control of cell growth and differentiation of human myeloblastic leukemia cells HL-60 is reported. Treatment with peptide slightly slows down the rate of cellular proliferation and this effect becomes more evident in cells grown for several weeks in the presence of the effector. An enhanced effect (40-50% inhibition respect to the control) is found in reversibly permeabilized cells and after 1% DMSO is added to the medium. Moreover the presence of peptide markedly increases the percentage of cells differentiated by DMSO and RA. The effect in DMSO-induced cells is more evident than that observed in RA-induced cells. This in agreement with our hypothesis that DMSO facilitates the peptide entry and its effect is due to an intracellular action.
Authors:
V Marsili; A Angiolillo; G L Gianfranceschi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  41     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-22     Completed Date:  1995-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  515-23     Citation Subset:  IM    
Affiliation:
Department of Cellular and Molecular Biology, University of Perugia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Cell Differentiation / drug effects
Cell Division / drug effects
Dimethyl Sulfoxide / pharmacology
Dose-Response Relationship, Drug
HL-60 Cells
Humans
Molecular Sequence Data
Peptides / chemical synthesis,  chemistry,  pharmacology*
Tretinoin / pharmacology
Chemical
Reg. No./Substance:
0/Peptides; 302-79-4/Tretinoin; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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