| Synthetic octapeptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn promotes differentiation in promyelocytic HL-60 cell line. | |
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MedLine Citation:
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PMID: 7549788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of the octapeptide pyroGlu-Asp-Asp-Ser-Asp-Glu-Glu-Asn in the control of cell growth and differentiation of human myeloblastic leukemia cells HL-60 is reported. Treatment with peptide slightly slows down the rate of cellular proliferation and this effect becomes more evident in cells grown for several weeks in the presence of the effector. An enhanced effect (40-50% inhibition respect to the control) is found in reversibly permeabilized cells and after 1% DMSO is added to the medium. Moreover the presence of peptide markedly increases the percentage of cells differentiated by DMSO and RA. The effect in DMSO-induced cells is more evident than that observed in RA-induced cells. This in agreement with our hypothesis that DMSO facilitates the peptide entry and its effect is due to an intracellular action. |
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Authors:
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V Marsili; A Angiolillo; G L Gianfranceschi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular and molecular biology (Noisy-le-Grand, France) Volume: 41 ISSN: 0145-5680 ISO Abbreviation: Cell. Mol. Biol. (Noisy-le-grand) Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-11-22 Completed Date: 1995-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216789 Medline TA: Cell Mol Biol (Noisy-le-grand) Country: FRANCE |
Other Details:
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Languages: eng Pagination: 515-23 Citation Subset: IM |
Affiliation:
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Department of Cellular and Molecular Biology, University of Perugia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Cell Differentiation / drug effects Cell Division / drug effects Dimethyl Sulfoxide / pharmacology Dose-Response Relationship, Drug HL-60 Cells Humans Molecular Sequence Data Peptides / chemical synthesis, chemistry, pharmacology* Tretinoin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 302-79-4/Tretinoin; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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