Document Detail


Synthetic multicellular cell-to-cell communication in inkjet printed bacterial cell systems.
MedLine Citation:
PMID:  21208654     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We utilized a commercially available materials printer to investigate synthetic multicellular cell-to-cell communication because inkjet printing technology makes it easy to print spatiotemporal patterns of soluble biomolecules and live cells. Since cells are genetically programmed to communicate with one another via synthetic biology, cell signaling molecules secreted by one cell microcolony can induce two neighboring cell microcolonies to respond by expressing or stopping the expression of fluorescent protein genes. In this work, we not only characterize the printing parameters such as the initial seeding numbers, spacing distances, microcolony sizes, printing timings, and printed patterns of cells but also demonstrate that the use of the proposed printing technology can provide a useful means for many synthetic biologists to simplify and speed up the investigation of cell-to-cell communication between synthetic bacterial cells.
Authors:
Woon Sun Choi; Dokyeong Ha; Seongyong Park; Taesung Kim
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Publication Detail:
Type:  Journal Article     Date:  2011-01-03
Journal Detail:
Title:  Biomaterials     Volume:  32     ISSN:  1878-5905     ISO Abbreviation:  Biomaterials     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  2500-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
School of Mechanical and Advanced Materials Engineering, Ulsan National Institute of Science and Technology (UNIST), 100 Banyeon-ri, Ulsan 689-798, Republic of Korea.
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