| Synthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspases. | |
| | |
MedLine Citation:
|
PMID: 22546669 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A series of alkyl α/β-(1→6)-diglucopyranosides 1-12 were synthesized and assessed for cytotoxicity against HL-60, U937, Molt-3 and MCF-7 cancer cell lines. The menthyl derivatives displayed strong cytotoxic properties showing IC(50) values between 6 and 16μM. Furthermore, we demonstrated that the selected synthetic (+)-menthyl β-(1→6)-diglucopyranoside 5 induces apoptotic cell death in human leukemia cells through a mechanism that involves activation of multiple caspases. Cell death was completely prevented by the non-specific caspase inhibitor z-VAD-fmk and found to be associated with the release of cytochrome c, an increase in the expression of Bax levels and a decrease in the generation of reactive oxygen species. |
| | |
Authors:
|
María Teresa Marrero; Sara Tejera; Sara Estévez; José Quintana; Carlos Mayato; Rosa L Dorta; Jesús T Vázquez; Francisco Estévez |
Related Documents
:
|
21116689 - Growth and differentiation factor 9 (gdf-9) induces epithelial-mesenchymal transition i... 22783399 - Ccn3 (nov) regulates proliferation, adhesion, migration and invasion in clear cell rena... 7294539 - Segmentation of papanicolaou smear images. 6775139 - Citrullinaemia: the possibility of prenatal diagnosis. 22659209 - Functional ionic liquids induced the formation of mitochondria targeted fluorescent cor... 22324039 - Hypertonic saline downregulate the production level of lipopolysaccharide-induced migra... 18280799 - Immunohistochemical characterization of the rat carotid body. 16663929 - Conversion and distribution of cobalamin in euglena gracilis z, with special reference ... 18034159 - An acetylation/deacetylation cycle controls the export of sterols and steroids from s. ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-13 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-5-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Departamento de Bioquímica, Unidad Asociada al Consejo Superior de Investigaciones Científicas, Universidad de Las Palmas de Gran Canaria, Instituto Canario de Investigación del Cáncer, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[...
Next Document: Remarkably fast and selective aromatization of Hantzsch esters with MoOCl(4) and MoCl(5): A chemical...