| Synthetic immune signaling. | |
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MedLine Citation:
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PMID: 22326912 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A successful immune response against pathogens requires the activation of different cell types of the immune system. These activation processes are difficult to study by classical biochemical and genetic methods alone. In this review we describe how approaches of synthetic biology, such as rebuilding of minimal functional signaling systems and the design of new molecules acting as signaling switches, can be used to get a deeper insight into the signaling mechanism of immune cells. In particular, the interaction of receptors with signal-transducing elements can be studied in detail with these new methods. In addition, sophisticated synthetic immune receptors are being tested in the clinic for gene therapy against certain cancer types. |
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Authors:
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Wolfgang Wa Schamel; Michael Reth |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-10 |
Journal Detail:
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Title: Current opinion in biotechnology Volume: - ISSN: 1879-0429 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100492 Medline TA: Curr Opin Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Center for Biological Signalling Studies BIOSS and Faculty of Biology, University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany; Center for Chronic Immunodeficiency CCI, University Clinics, Freiburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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