Document Detail


Synthetic delivery systems for intravenous administration of nucleic acids.
MedLine Citation:
PMID:  17716119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At present, there are no intravenously administered nucleic acid-based therapeutics that have been approved for human use. This reflects the difficulties in applying nucleic acid-based drugs: they are nuclease sensitive and have difficulties in reaching their site of action. Important challenges for intravenously administered nucleic acid formulations are the requirements that they can transport the nucleic acids efficiently in the circulation, have the ability to direct nucleic acids to the desired cell type and are able to steer their intracellular processing. Here, we evaluate nanotechnological strategies that improve the pharmacokinetics and colloidal stability of nucleic acids in the bloodstream, focus biodistribution towards the target tissue and facilitate interactions with and trafficking within the desired cell type.
Authors:
Raymond M Schiffelers; Holger K de Wolf; Inge van Rooy; Gert Storm
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nanomedicine (London, England)     Volume:  2     ISSN:  1748-6963     ISO Abbreviation:  Nanomedicine (Lond)     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-09-18     Revised Date:  2010-01-28    
Medline Journal Info:
Nlm Unique ID:  101278111     Medline TA:  Nanomedicine (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-81     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. r.m.schiffelers@pharm.uu.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Carriers / chemistry*
Gene Targeting / methods*
Gene Therapy / methods*
Humans
Injections, Intravenous / methods*
Nanomedicine / methods
Nanostructures / chemistry*
Nucleic Acids / administration & dosage*,  chemistry*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Nucleic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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