Document Detail

Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for adriamycin.
MedLine Citation:
PMID:  6253239     Owner:  NLM     Status:  MEDLINE    
An attempt to pre-set the circadian rhythm in murine chronotolerance for adriamycin (ADR) given i.p. or i.v. with ACTH was performed in three studies. In CDF1 mice standardized in LD12:12, it was demonstrated that 1) the circadian rhythm in murine chronotolerance for ADR exhibits a different timing depending upon whether the intravenous or intraperitoneal route is used for the administration of this anticancer agent; 2) ACTH or saline pretreatment does not enhance optimal circadian-stage-qualified ADR tolerance, whatever its route of injection, with any of the circadian stages and schedules explored; 3) near-optimal tolerance can be achieved by a fixed 'best' interval (among those investigated) between ACTH and ADR, irrespective of circadian stage. Tolerance equivalent to optimal circadian-stage-qualified ADR tolerance results from the administration of ACTH 1-17 (HOE433 = Synchrodyn) 24 hours before ADR injection; 4) and acrophase advance of over 6 hours of the tolerance rhythm results from ACTH 1-17 administration at 6 HALO. The acrophase changes do not directly account for an optimal ADR tolerance at a fixed interval of 24 hours after ACTH 1-17. Thus, ACTH may be considered a potential relative chronizer of murine chronotolerance for ADR.
F Levi; F Halberg; E Haus; S Sanchez de la Peña; R B Sothern; E Halberg; W Hrushesky; H Brown; L E Scheving; B J Kennedy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chronobiologia     Volume:  7     ISSN:  0390-0037     ISO Abbreviation:  Chronobiologia     Publication Date:    1980 Apr-Jun
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0434557     Medline TA:  Chronobiologia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  227-44     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology*
Circadian Rhythm / drug effects*
Doxorubicin / toxicity*
Drug Tolerance
Peptide Fragments / pharmacology*
Sex Factors
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 20566-04-5/acethropan-S; 23214-92-8/Doxorubicin; 9002-60-2/Adrenocorticotropic Hormone

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