| Synthetic inositol phosphoglycans related to GPI lack insulin-mimetic activity. | |
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MedLine Citation:
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PMID: 20825209 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Insulin signaling has been suggested, at least in part, to be affected by an insulin-mimetic species of low molecular weight. These inositol phosphoglycans (IPGs) are generated upon growth hormone/cytokine stimulation and control the activity of a multitude of insulin effector enzymes. The minimal structural requirements of IPGs for insulin-mimetic action have been debated. Two types of IPGs were suggested, and the IPG-A type resembles the core glycan of glycosylphosphatidylinositol (GPI)-anchors. In fact, purified GPI-anchors of lower eukaryotic origin have been shown to influence glucose homeostasis. To elucidate active IPGs, a collection of synthetic IPGs designed on the basis of previous reports of activity were tested for their insulin-mimetic activity. In vitro and ex vivo assays in rodent adipose tissue as well as in vivo analyses in mice were employed to test the synthetic IPGs. None of the IPGs we tested mimic insulin actions as determined by PKB/Akt phosphorylation and quantification of glucose transport and lipogenesis. Furthermore, none of the IPGs had any effect in in vivo insulin tolerance assays. In stark contrast to previous claims, we conclude that neither of the compounds tested is insulin-mimetic. |
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Authors:
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Marie-Lyn Hecht; Yu-Hsuan Tsai; Xinyu Liu; Christian Wolfrum; Peter H Seeberger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ACS chemical biology Volume: 5 ISSN: 1554-8937 ISO Abbreviation: ACS Chem. Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101282906 Medline TA: ACS Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1075-86 Citation Subset: IM |
Affiliation:
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Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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