| Synthetic Caged DAG-lactones for Photochemically Controlled Activation of Protein Kinase C. | |
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MedLine Citation:
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PMID: 22238145 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Switching on kinases: Synthetic caged DAG-lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade. |
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Authors:
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Wataru Nomura; Tetsuo Narumi; Nami Ohashi; Yuki Serizawa; Nancy E Lewin; Peter M Blumberg; Toshiaki Furuta; Hirokazu Tamamura |
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Publication Detail:
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Type: Journal Article Date: 2011-01-18 |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: 12 ISSN: 1439-7633 ISO Abbreviation: Chembiochem Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2012-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: Germany |
Other Details:
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Languages: eng Pagination: 535-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062 (Japan), Fax:(+81) 3-5280-8039. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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