Document Detail

Synthetic adipose tissue models for studying mammary gland development and breast tissue engineering.
MedLine Citation:
PMID:  20835885     Owner:  NLM     Status:  MEDLINE    
The mammary gland is a dynamic organ that continually changes its architecture and function. Reciprocal interactions between epithelium and adipocyte-containing stroma exert profound effects on all stages of its development, even though the details of these events are not fully understood. To address this issue, enormous potential exists in the utilization of synthetic adipose tissue model systems to uncover the properties and functions of adipocytes in the mammary gland. The first part of this review focuses on mammary adipose tissue (or adipocyte)-related model systems developed in recent years and their utility in investigating adipose-epithelial interactions, mammary gland morphogenesis, development and tumorigenesis. The second part shifts to the field of adipose-based breast tissue engineering, focusing on how these synthetic adipose tissue models are being constructed in vitro or in vivo for regeneration of the mammary gland, and their potentials in adipose tissue engineering also are discussed.
Xiuli Wang; Michaela R Reagan; David L Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-09-12
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  15     ISSN:  1573-7039     ISO Abbreviation:  J Mammary Gland Biol Neoplasia     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-11     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-76     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / physiology*
Cell Differentiation
Mammary Glands, Animal / physiology*
Mammary Glands, Human / physiology*
Tissue Engineering / methods*
Grant Support

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