Document Detail

Synthesis of valproyl-2-pyrrolidinone and its evaluation as a cognitive drug with the ability to modulate acidic amino acids in the brain.
MedLine Citation:
PMID:  1971306     Owner:  NLM     Status:  MEDLINE    
A new pyrrolidinone derivative, valproyl-2-pyrrolidinone (VP), was synthesized, followed by evaluation as a cognitive drug. VP gave rise to a significant protective effect against cerebral anoxia together with a potent prolongation of latency time for the reversal of scopolamine induced transient disruption of the memory of a passive avoidance response in rats. The quantitative experiment using HPLC demonstrated a significant reduction of hippocampal aspartate (Asp) and glutamate (Glu) following the intraperitoneal administration of VP at a dose of 300 mg/kg.
C Miyazaki; K Matsuyama; M Ichikawa; S Goto; J Yamamoto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  13     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  IM    
Department of Hospital Pharmacy, Nagasaki University Hospital, Japan.
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MeSH Terms
Administration, Oral
Aspartic Acid / metabolism*
Behavior, Animal / drug effects
Brain / metabolism*
Cognition / drug effects*
Glutamates / metabolism*
Glutamic Acid
Hippocampus / metabolism
Pantothenic Acid / analogs & derivatives,  pharmacology
Pyrrolidinones / administration & dosage,  chemical synthesis,  pharmacology*
Rats, Inbred Strains
gamma-Aminobutyric Acid / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Glutamates; 0/Pyrrolidinones; 120425-64-1/valproyl-2-pyrrolidinone; 1977-33-9/pantogab; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 72432-10-1/aniracetam; 79-83-4/Pantothenic Acid

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