| Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid. | |
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MedLine Citation:
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PMID: 18407636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Structural DNA nanotechnology relies on Watson-Crick base pairing rules to assemble DNA motifs into diverse arrangements of geometric shapes and patterns. While substantial effort has been devoted to expanding the programmability of natural DNA, considerably less attention has been given to the development of nucleic acid structures based on non-natural DNA polymers. Here we describe the use of glycerol nucleic acid (GNA), a simple polymer based on an acyclic repeating unit, as an alternative genetic material for assembling nucleic acid nanostructures independent of RNA or DNA recognition. We synthesized two 4-helix junctions based entirely on GNA self-pairing and showed that GNA provides easy access to highly stable nanostructures with left- and right-handed helical configurations. |
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Authors:
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Richard S Zhang; Elizabeth O McCullum; John C Chaput |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-12 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 130 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-30 Completed Date: 2008-06-23 Revised Date: 2008-12-15 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 5846-7 Citation Subset: IM |
Affiliation:
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Center for BioOptical Nanotechnology, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Circular Dichroism DNA / chemical synthesis, chemistry Electrophoresis Glycerol / analogs & derivatives*, chemistry Models, Molecular Nanostructures / chemistry* Nucleic Acid Conformation Nucleic Acids / chemical synthesis*, chemistry Oligonucleotides / chemical synthesis*, chemistry Organophosphorus Compounds / chemical synthesis, chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Oligonucleotides; 0/Organophosphorus Compounds; 0/phosphoramidite; 56-81-5/Glycerol; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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