| Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine. | |
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MedLine Citation:
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PMID: 2428619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[18F]-5-fluorocytosine-arabinoside (2) and [18F]-5-fluorocyclocytidine (4) were prepared by reaction of [18F]-acetylhypofluorite with cytosine-arabinoside (1) or cyclocytidine (3) in acetic acid and were isolated in an overall radiochemical yield of 20% and 9%, respectively. The biodistribution of both radiopharmaceuticals was determined in melanoma bearing Syrian golden hamsters. It was found that 2 is a good tumour-localizing agent for pigmented and non-pigmented Greene melanoma. |
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Authors:
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G W Visser; O Zwaagstra; G C Gorree; P Moonen; J D Herscheid; A Hoekstra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 12 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1986 |
Date Detail:
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Created Date: 1986-11-10 Completed Date: 1986-11-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 137-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ancitabine
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diagnostic use Animals Cricetinae Cytarabine / diagnostic use* Flucytosine / diagnostic use* Fluorine / diagnostic use* Melanoma, Experimental / radionuclide imaging* Mesocricetus Radioisotopes / diagnostic use* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 147-94-4/Cytarabine; 2022-85-7/Flucytosine; 31698-14-3/Ancitabine; 7782-41-4/Fluorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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