Document Detail


Synthesis and tumor inhibiting activity of lanthanum (III) complexes with some 1-aminocycloalkancarboxylic acids.
MedLine Citation:
PMID:  8999429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Complexes of La(III) with 1-aminocyclopentane-, -hexane, -heptane and -4-ethylcyclohexanecarboxylic acids were obtained. The compounds were characterized by elemental analyses, IR spectroscopy and conductivity measurements. The following general formula was derived: LaL3Cl3 x 5 H2O, where L is the corresponding 1-aminocycloalkanecarboxylic acid. The pharmacological studies showed that all complexes manifested higher cytostatic and cytotoxic effects in comparison with lanthanum chloride. Much higher cytotoxic (anti-P388/D1) and cytostatic (anti-L-1210 and anti-melanoma-B16) activity was found for the lanthanum complex with 1-aminocyclopentanecarboxylic acid.
Authors:
T B Kovachev; D S Ivanov; R T Buyukliev; S M Konstantinov; M C Karaivanova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  51     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Higher Medical School, Sofia, Bulgaria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemical synthesis*,  pharmacology
Chemistry, Physical
Lanthanum / pharmacology
Leukemia L1210 / drug therapy
Leukemia P388 / drug therapy
Ligands
Melanoma, Experimental / drug therapy
Mice
Organometallic Compounds / chemical synthesis*,  pharmacology
Physicochemical Phenomena
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Ligands; 0/Organometallic Compounds; 7439-91-0/Lanthanum

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