Document Detail


Synthesis of a trigalacturonic acid analogue mimicking the expected transition state in the glycosidases.
MedLine Citation:
PMID:  20138256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A trigalacturonic acid analogue carrying a cyclohexene framework in place of the central pyranose ring was synthesized as a molecular probe for the mechanistic investigation of endo-polygalacturonase 1 (endo-PG 1). Preliminary enzymatic studies revealed that this analogue inhibited endo-PG 1 activity by about 30% at 0.3mM concentration.
Authors:
Kazunori Yamamoto; Shogo Noguchi; Noboru Takada; Kazuo Miyairi; Masaru Hashimoto
Related Documents :
25047196 - Balanoposthitis with epithelial dysplasia treated by photodynamic therapy.
8863796 - Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase ...
8759636 - Structure-activity relationships of (e)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-p...
17190446 - Engineering of the spinosyn pks: directing starter unit incorporation.
2210676 - Transport of chenodeoxycholic acid and its 3-alpha- and 7-alpha-sulfates by isolated pe...
1888776 - Fatty acid remodelling of phosphatidylinositol under conditions of de novo synthesis in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-29
Journal Detail:
Title:  Carbohydrate research     Volume:  345     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  572-85     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Faculty of Agriculture and Life Science, Hirosaki University, 3-Bunkyo-cho, Hirosaki 036-8561, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Hexuronic Acids / chemistry*
Models, Molecular
Molecular Mimicry*
Polygalacturonase / chemistry*,  metabolism*
Substrate Specificity
Chemical
Reg. No./Substance:
0/Hexuronic Acids; 14982-50-4/galacturonic acid; EC 3.2.1.15/Polygalacturonase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simulating Neurocognitive Aging: Effects of a Dopaminergic Antagonist on Brain Activity During Worki...
Next Document:  A kinetic study on the chemical cleavage of nucleoside diphosphate sugars.