Document Detail

Synthesis of a trigalacturonic acid analogue mimicking the expected transition state in the glycosidases.
MedLine Citation:
PMID:  20138256     Owner:  NLM     Status:  MEDLINE    
A trigalacturonic acid analogue carrying a cyclohexene framework in place of the central pyranose ring was synthesized as a molecular probe for the mechanistic investigation of endo-polygalacturonase 1 (endo-PG 1). Preliminary enzymatic studies revealed that this analogue inhibited endo-PG 1 activity by about 30% at 0.3mM concentration.
Kazunori Yamamoto; Shogo Noguchi; Noboru Takada; Kazuo Miyairi; Masaru Hashimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-29
Journal Detail:
Title:  Carbohydrate research     Volume:  345     ISSN:  1873-426X     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  572-85     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Faculty of Agriculture and Life Science, Hirosaki University, 3-Bunkyo-cho, Hirosaki 036-8561, Japan.
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MeSH Terms
Hexuronic Acids / chemistry*
Models, Molecular
Molecular Mimicry*
Polygalacturonase / chemistry*,  metabolism*
Substrate Specificity
Reg. No./Substance:
0/Hexuronic Acids; 14982-50-4/galacturonic acid; EC

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