Document Detail


SYNTHESIS OF TRIFLUOROMETHYL-IMINES BY SOLID ACID/SUPERACID CATALYZED MICROWAVE ASSISTED APPROACH.
MedLine Citation:
PMID:  21949445     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new solid acid/superacid catalyzed microwave assisted synthesis of trifluoromethyl-imines is described. Various α,α,α-trifluoromethylketones react readily with primary amines to produce the corresponding imines. Two different strategies have been employed; one is the application of microwave irradiation coupled with solvent-free solid acid catalysis. The other method, for highly deactivated substrates includes the use of a pressure vessel at 175 °C temperature, with solid superacid catalysis. Using the solid acid K-10 montmorillonite or the superacidic perfluorinated resinsulfonic acid Nafion-H, a wide variety of trifluoromethylated imines have been synthesized using the above methods. The products have been isolated in good to excellent yields and high selectivities. This new environmentally friendly synthetic methodology provides significantly higher yields than traditional methods during relatively short reaction times for the preparation of the target compounds.
Authors:
Mohammed Abid; Markku Savolainen; Shainaz Landge; Jinbo Hu; G K Surya Prakash; George A Olah; Béla Török
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of fluorine chemistry     Volume:  128     ISSN:  0022-1139     ISO Abbreviation:  -     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373322     Medline TA:  J Fluor Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  587-594     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA 02132-3393, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R15 AG025777-02//NIA NIH HHS

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