Document Detail


Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.
MedLine Citation:
PMID:  8057294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to diagnose patients with medium-chain acyl-CoA dehydrogenase deficiency with a noninvasive diagnostic technique such as positron emission tomography, we have developed a synthesis of [omega-11C]palmitic acid. The radiochemical synthesis was achieved by coupling an alkylfuran Grignard reagent (7) with [11C]methyl iodide, followed by rapid oxidative cleavage of the furan ring to the carboxylate using ruthenium tetraoxide. Tissue biodistribution studies in rats comparing [omega-11C]palmitic acid and [1-11C]palmitic acid show that the %ID/g and %ID/organ in the heart tissue after administration of [omega-11C]palmitic acid is approximately 50% greater than after administration of [1-11C]palmitic acid, due to the diminished metabolism of the [omega-11C]palmitic acid. These studies show as well, low uptake in nontarget tissues (blood, lung, kidney, and muscle). PET images of a dog heart obtained after administration of [omega-11C]-and [1-11C]palmitic acid show virtually identical uptake and distribution in the myocardium. The differing cardiac washout of labeled palmitates measured by dynamic PET studies may allow diagnosis of disorders in cardiac fatty acid metabolism.
Authors:
B O Buckman; H F VanBrocklin; C S Dence; S R Bergmann; M J Welch; J A Katzenellenbogen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  37     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-09-12     Completed Date:  1994-09-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2481-5     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Illinois, Urbana 61801.
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MeSH Terms
Descriptor/Qualifier:
Acyl-CoA Dehydrogenase
Acyl-CoA Dehydrogenases / deficiency
Animals
Carbon Radioisotopes
Contrast Media
Dogs
Female
Heart / radionuclide imaging
Humans
Lipid Metabolism, Inborn Errors / diagnosis
Myocardium / metabolism*
Oxidation-Reduction
Palmitic Acid
Palmitic Acids / chemical synthesis,  metabolism,  pharmacokinetics*
Radiochemistry
Rats
Rats, Sprague-Dawley
Tissue Distribution
Tomography, Emission-Computed
Grant Support
ID/Acronym/Agency:
5R01 CA25836/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Contrast Media; 0/Palmitic Acids; 57-10-3/Palmitic Acid; EC 1.3.-/Acyl-CoA Dehydrogenases; EC 1.3.99.3/Acyl-CoA Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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