Document Detail

Synthesis of tetracalcium phosphate from mechanochemically activated reactants and assessment as a component of bone cements.
MedLine Citation:
PMID:  18305903     Owner:  NLM     Status:  MEDLINE    
The aim of this work was to gain a better understanding about the synthesis of tetracalcium phosphate (TTCP, Ca(4)(PO(4))(2)O) through a solid-state reaction from mechanochemically activated CaCO(3)-(NH(4))(2)HPO(4) mixtures. The evolution of the reaction was followed by DTA, XRD, FTIR and SEM techniques. An enhanced reactivity of the mixtures was detected as the mechanochemical treatment times increased. This effect was related to both the loss of crystallinity of the reactants and the production of defects on their surfaces. 6 h of mechanochemical processing at 1190 rpm, followed by 3 h of thermal treatment at 1500 degrees C, were enough to obtain pure TTCP. The crystallinity and purity of the obtained TTCP were checked by XRD and FTIR. The morphologic characteristics were analyzed by SEM and BET analysis. The behavior of synthesized TTCP powder in combination with commercial dicalcium phosphate anhydrous (DCPA, CaHPO(4)), as the solid phase of bone cements, was tested. Both the combination of different particle sizes of TTCP and DCPA and the effect of different kinds of accelerator agents (disodium hydrogen phosphate, tartaric acid, citric acid and oxalic acid) on setting time and degree of conversion to hydroxyapatite (HA, Ca(10)(PO(4))(6)(OH)(2)) were evaluated. The combination of TTCP (0.32 m(2)/g) with DCPA (1.52 m(2)/g), in a 1/1 molar ratio, showed the shortest setting times and high conversions to HA when an oxalic acid solution (5% volume fraction) was used as the liquid phase of the formulation. Results obtained from this work demonstrated that synthesized TTCP shows promising behavior as a component of bone cements, exhibiting not only a smaller particle size than that usually reported but also a low degree of crystallinity, all of which increases the reactivity of the obtained TTCP. This study provided a very efficient method for synthesizing pure TTCP through a modified solid-state reaction from mechanochemically activated reactants, employing very short times of thermal treatment in comparison with the conventional processes.
H E Romeo; M A Fanovich
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-29
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  19     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2009-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2751-60     Citation Subset:  IM    
Institute of Materials Science and Technology, University of Mar del Plata and National Research Council, Mar del Plata, Argentina.
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MeSH Terms
Bone Cements / chemistry*
Calcium Phosphates / chemistry*
Materials Testing
Particle Size
Stress, Mechanical
Surface Properties
Reg. No./Substance:
0/Bone Cements; 0/Calcium Phosphates; 0/tetracalcium phosphate

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