Document Detail

Synthesis of a tetra- and a trisaccharide related to an anti-tumor saponin "Julibroside J28" from Albizia julibrissin.
MedLine Citation:
PMID:  17701454     Owner:  NLM     Status:  MEDLINE    
Simple and convergent synthesis of a tetra- and a trisaccharide portions of an antitumor compound Julibroside J(28), isolated from Albizia julibrissin, that showed significant in vitro antitumor activity against HeLa, Bel-7402 and PC-3M-1E8 cancer cell lines is reported. The tetrasaccharide has been synthesized as its p-methoxyphenyl glycoside starting from commercially available D-glucose, L-rhamnose and L-arabinose. The trisaccharide part has been synthesized from commercially available N-acetyl D-glucosamine, D-fucose and D-xylose using simple protecting group manipulations. Sulfuric acid immobilized on silica has been used successfully as a Brönsted acid catalyst for the crucial glycosylation steps.
Bimalendu Roy; Kausikisankar Pramanik; Balaram Mukhopadhyay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-16
Journal Detail:
Title:  Glycoconjugate journal     Volume:  25     ISSN:  0282-0080     ISO Abbreviation:  Glycoconj. J.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8603310     Medline TA:  Glycoconj J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-66     Citation Subset:  IM    
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226 001 Uttar Pradesh, India.
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MeSH Terms
Albizzia / chemistry*
Antineoplastic Agents, Phytogenic / chemical synthesis*,  pharmacology
Carbohydrate Sequence
Hela Cells
Molecular Sequence Data
Saponins / chemistry*,  pharmacology
Trisaccharides / chemical synthesis*,  pharmacology
Triterpenes / chemistry*,  pharmacology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Trisaccharides; 0/Triterpenes; 0/julibroside J28

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