| Synthesis of a tetra- and a trisaccharide related to an anti-tumor saponin "Julibroside J28" from Albizia julibrissin. | |
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MedLine Citation:
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PMID: 17701454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Simple and convergent synthesis of a tetra- and a trisaccharide portions of an antitumor compound Julibroside J(28), isolated from Albizia julibrissin, that showed significant in vitro antitumor activity against HeLa, Bel-7402 and PC-3M-1E8 cancer cell lines is reported. The tetrasaccharide has been synthesized as its p-methoxyphenyl glycoside starting from commercially available D-glucose, L-rhamnose and L-arabinose. The trisaccharide part has been synthesized from commercially available N-acetyl D-glucosamine, D-fucose and D-xylose using simple protecting group manipulations. Sulfuric acid immobilized on silica has been used successfully as a Brönsted acid catalyst for the crucial glycosylation steps. |
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Authors:
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Bimalendu Roy; Kausikisankar Pramanik; Balaram Mukhopadhyay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-16 |
Journal Detail:
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Title: Glycoconjugate journal Volume: 25 ISSN: 0282-0080 ISO Abbreviation: Glycoconj. J. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-08 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603310 Medline TA: Glycoconj J Country: United States |
Other Details:
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Languages: eng Pagination: 157-66 Citation Subset: IM |
Affiliation:
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Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226 001 Uttar Pradesh, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albizzia
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chemistry* Antineoplastic Agents, Phytogenic / chemical synthesis*, pharmacology Carbohydrate Sequence Hela Cells Humans Molecular Sequence Data Saponins / chemistry*, pharmacology Trisaccharides / chemical synthesis*, pharmacology Triterpenes / chemistry*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Trisaccharides; 0/Triterpenes; 0/julibroside J28 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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