Document Detail


Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.
MedLine Citation:
PMID:  17566735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Herein we report the synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [14C]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium.
Authors:
Ashish K Pathak; Vibha Pathak; James R Riordan; William J Suling; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-06
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-11-21     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4527-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / chemical synthesis*,  pharmacology
Disaccharides / chemical synthesis*,  pharmacology*
Mycobacterium tuberculosis / enzymology*
Pentosyltransferases / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
G0500590//Medical Research Council; R01 AI045317/AI/NIAID NIH HHS; R01 AI045317-04/AI/NIAID NIH HHS; R01AI45317/AI/NIAID NIH HHS; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Disaccharides; EC 2.4.2.-/Pentosyltransferases; EC 2.4.2.-/arabinosyltransferase
Comments/Corrections

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